Asymmetric reactions in sonochemistry

Sonochemistry and sonoluminescence in microfluidics.

One way to focus the diffuse energy of a sound field in a liquid is by acoustically driving bubbles into nonlinear oscillation. A rapid and nearly adiabatic bubble collapse heats up the bubble interior and produces intense concentration of energy that is able to emit light (sonoluminescence) and to trigger chemical reactions (sonochemistry). Such phenomena have been extensively studied in bulk ...

Asymmetric reactions in continuous flow

An overview of asymmetric synthesis in continuous flow and microreactors is presented in this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed.

Organocatalysed asymmetric Mannich reactions.

The asymmetric Mannich reaction ranks among the most potent enantioselective and diastereoselective C-C-bond forming reactions. In recent years, organocatalysed versions of asymmetric Mannich processes have been increasingly reported and used in a rapidly growing number of applications. This tutorial review provides an overview of the recent history of the asymmetric organocatalysed Mannich rea...

Asymmetric strecker reactions.

Iron-catalyzed asymmetric haloamination reactions.

The first iron(III)/N,N'-dioxide-catalyzed asymmetric haloamination of 3-alkylidene- and 3-arylidene-indolin-2-ones was developed, affording the corresponding chiral oxindole derivatives bearing vicinal haloamine substituents with excellent results (up to 99% yield, 99% ee, >19 : 1 dr). This iron catalyst also exhibits perfect enantioselectivity for chalcone derivatives. The cooperative activat...